Electrical stimulation increases trigeminal ganglia neuron excitability in conscious migraine


  • In a rat model of conscious migraine, electrical stimulation (ES)  application significantly increases the excitability of small-sized trigeminal ganglia (TG) neurons in both IB4-negative and IB4-positive neurons.

Why this matters

  • The observed neuronal excitability of peripheral sensory neurons and subsequent synaptic transmission in a conscious, rather than anesthetized, animal model offers insights into opportunities for analgesic pharmacotherapy and potential targets for migraine treatment.