Electroencephalography to predict seizure freedom following epilepsy surgery

Takeaway

  • A predictive model was generated using pre-surgical electroencephalography (EEG) to supplement clinical factors, achieving a concordance (c)-index of 0.65. Interictal epileptiform dischargers (IEDs) were important factors in predicting seizure freedom.

Why this matters

  • Resective epilepsy surgery is the best treatment available for people with drug-resistant focal epilepsy, with 40–80% of patients achieving complete seizure freedom.

  • Finding pre-surgical factors associated with the best chance of post-surgical seizure freedom has been a priority. Currently, predicting whether a patient will benefit from epilepsy surgery occurs on a case-by-case basis per subjective clinical assessment. Development of a predictive model would provide a more objective and quantifiable assessment of treatment outcomes.

  • EEGs are an essential tool in the diagnosis and management of epilepsy. It is possible that EEG data could be combined with clinical data to create effective and objective predictive models of post-surgical outcomes.