Enlarged perivascular spaces have limited clinical significance in early Alzheimer’s disease

Takeaway

  • Enlarged perivascular spaces are associated with small vessel disease, but not Alzheimer’s disease, and their clinical significance appears to be minimal.

Why this matters

    These findings support the hypothesis that enlarged perivascular spaces is a marker for small vessel disease but suggest that a role for enlarged perivascular spaces in the early pathogenesis of Alzheimer’s disease is limited.