Epilepsy risk among survivors of intensive care unit hospitalization for sepsis

Takeaway

  • Sepsis survivors were significantly more likely to develop epilepsy in the two years following their discharge from an intensive care unit (ICU), with those who are younger and have comorbid chronic kidney disease (CKD) being at highest risk.

Why this matters

  • Altered mental activity, or encephalopathy, is one of the characteristics of sepsis - a systemic infection that causes organ dysfunction.

  • Sepsis survivors who continue to experience seizures are at increased risk of morbidity and mortality.

  • In 35% of focal epilepsy cases, the etiology of the seizures is unknown, suggesting the existence of yet unidentified risk factors.