Epileptiform abnormalities and seizures in Alzheimer’s disease

Takeaway

  • Specific features of epileptiform discharges are associated with clinical seizures in Alzheimer’s disease (AD), particularly right temporal hyperexcitability, which could potentially be classed as an AD electrical biomarker.

Why this matters

  • Neuronal excitability has a putative role in memory failure in early AD and disease progression and may be associated with accelerated cognitive decline.

  • Electroencephalogram (EEG) markers could help to identify AD patients at potentially high seizure risk as well as guiding development of novel AD therapeutics focused on the temporal lobe and associated pathways involved in hyperexcitability.