Epileptiform activity during rapid eye movement sleep is associated with poorer disease trajectory

Takeaway

  • In people under observation at an epilepsy monitoring unit, increased epileptiform activity during rapid eye movement (REM) sleep is associated with increased peak seizure frequency, which suggests an overall poorer epilepsy trajectory.

Why this matters

  • Monitoring of the proportion of REM sleep occupied by interictal epileptiform discharges (IED) could be a useful biomarker for epilepsy prognosis.

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