Establishing multiple sleep latency test cutoffs to diagnose narcolepsy type 1 in children


  • New multiple sleep latency test (MSLT) cutoffs are valid and reliable in children to detect narcolepsy type 1 (NT1).

Why this matters

  • NT1 in children is caused by a hypocretin-1 (hcrt-1) deficiency, and measurement of cerebrospinal hcrt-1 is considered the gold standard of diagnosis for this disorder.

  • Children with NT1 are given a polysomnography (PSG) and MSLT to confirm diagnosis; however, result interpretation is based on adult sleep data, as children-specific cutoffs have not been studied.