Estradiol and visceral adipose tissue: do they impact brain aging and memory?


  • Visceral adipose tissue (VAT) moderates the association between age and network covariance among men and women.

  • Estradiol moderates the association between VAT and memory network covariance in women; lower levels of estradiol may be linked to poorer memory performance.

Why this matters

  • Healthy cognitive aging could be facilitated by gender-specific treatments as well as management approaches to address excessive VAT.

  • In particular, physicians should assess women for VAT and estradiol to ensure healthy brain aging.