Evaluating retinal neuronal pathology in individuals with stiff-person syndrome


  • Individuals with stiff-person syndrome (SPS) had lower ganglion cell + inner plexiform layer (GCIPL) and inner nuclear layer (INL) thickness, lower visual acuity (VA) scores, and high levels of anti–glutamic acid decarboxylase (anti-GAD65) antibodies suggesting the occurrence of retinal neuronal pathology in SPS.

Why this matters

    SPS is a rare neuro-immunological disorder in which isolated cases of SPS have reported visual dysfunction but none have measured visual outcome at a cohort level. The results of this study provide insight into the pathophysiology of SPS and suggest optical coherence tomography (OCT) scans might be used to reflect burden of disease.