Evaluating the Aβ-index as an estimate of Aβ load

Takeaway

  • The proposed amyloid-beta (Aβ) index is very well associated with standardized uptake value ratios (SUVR) and may be simpler to implement in clinical settings, because it does not require magnetic resonance imaging (MRI) nor definition of regions of interest (ROI).

Why this matters

    SUVR is the most commonly used quantitative measure for Aβ–positron emission tomography (PET) tracers and requires delineation of ROI through high-resolution MRI, which may not always be available or may be contraindicated; the Aβ-index is proposed as a novel measure of brain Aβ-burden that may be simpler to implement in clinical practice.