Evaluating the relationship between brain function and verbal working memory in amyotrophic lateral sclerosis

Takeaway

  • People with amyotrophic lateral sclerosis (ALS) have comparable behavioral performance with healthy controls (HC), but exhibit increased frontoparietal and temporal memory during working verbal memory tasks, suggesting compensatory effects in ALS.

Why this matters

    Studies have assessed the impact of ALS on working memory via behavioral and functional imaging measures, but few have evaluated underlying brain activity while in the process of performing these tasks. The current study provides evidence that people with ALS develop compensatory effects in frontoparietal and temporal memory, which may direct future treatment approaches.