Evaluation of brain-derived neurotrophic factor on motor and cognitive impairment in Parkinson’s disease


  • Overexpression of brain-derived neurotrophic factor (BDNF) significantly alleviated motor and cognitive impairment, suggesting that BDNF may have a neuroprotective effect.

Why this matters

  • BDNF has recently shown promise as a potential treatment for Alzheimer’s disease, but its role in Parkinson’s disease (PD) is unknown.

  • Results from this study indicate that BDNF may be a therapeutic candidate for mitochondrial impairment-associated neurodegenerative diseases.