Evaluation of hypoperfusion index in assessing rate of core progression in medium and large vessel stroke


  • Hypoperfusion index (HI) is related to the rate of core progression up to 24 hours in patients with medium vessel occlusion (MeVO) and large vessel occlusion (LVO), with HI >0.5 distinguishing fast from slow progressors.

Why this matters

  • Most current studies of HI have focused on patients with LVO within the first 6–8 hours following stroke onset, but treatment windows for intervention are up to 24 hours.

  • This study, the first to evaluate performance of HI to evaluate core progression within 24 hours of stroke onset, offers evidence that can aid clinicians in treatment decisions.