Evaluation of movement-related electroencephalogram signatures in Parkinson’s disease with freezing of gait


  • Parkinson’s disease (PD) patients with freezing of gait (FOG) exhibit motor cortical activities that differ from healthy controls (HC) and people with PD without FOG, and there are significant differences in motor cortical activities between PD with mild or severe FOG.

Why this matters

  • FOG is a complicated and disabling PD symptom with poorly understood underlying mechanisms and limited treatment options.

  • Results from this study support important involvement of the motor cortex in FOG pathophysiology, which may lead to detection biomarkers and new treatment and rehabilitation options for people with PD and FOG.