Evaluation of retinal nerve fiber layer thickness in people with multiple sclerosis with and without optic neuritis

Takeaway

  • Progressive changes in retinal nerve fiber layer (RNFL) thickness occur in people with multiple sclerosis (MS), regardless of optic neuritis (ON) presence, and a significant reduction in in RNFL occurs with MS disease progression in the presence of ON.

Why this matters

  • ON is a common manifestation of MS, and reduced RNFL thickness has been proposed as a biomarker of MS disability and progression.

  • This study suggests that measurement of RNFL thickness may provide a biomarker for evaluating MS disease progression and its relationship with ON.