Evidence for the need for cardiac assessments in people with alternating hemiplegia of childhood


  • Cardiac abnormalities were found in the majority of people with ATP1A3-related syndromes, including a need for cardiac intervention in ~3% of people with the alternating hemiplegia of childhood phenotype.

Why this matters

    The authors suggest that cardiac assessments should be undertaken in people with ATP1A3-related syndromes as part of checking if patients are at risk of sudden cardiac death and may benefit from a pacemaker or implantable cardioverter-defibrillator.