Evoked field potential measurement during intermittent deep brain simulation in rats

Takeaway

  • Intermittent hippocampal deep brain stimulation (DBS) reduces the field excitatory postsynaptic potential (fEPSP) slope on both long and short timescales in free moving rats.

Why this matters

  • DBS is used in the treatment of various neuropsychiatric disorders, however, little is known about its mode of action (MoA).

  • The use of evoked field potentials (EPs) allows for the measurement of postsynaptic input, output and intrinsic excitability and is therefore a useful tool to aid understanding of the MoA of DBS.