Examining cardiac sympathetic nerve degeneration in dementia with Lewy bodies


  • Patients suffering from dementia with Lewy bodies (DLB) with broad, early stage (Lewy body) LB pathology in the brain, may show mild cardiac sympathetic nerve (CSN) degeneration.

Why this matters

  • Differentiating between DLB and Alzheimer's disease (AD) is difficult because both LB and AD pathology can coexist in DLB patients.

  • Reduced cardiac uptake of meta-iodobenzylguanidine (MIBG) is a useful diagnostic biomarker for differentiating DLB from other dementias, including AD.

  • By understanding residual CSN degeneration in autopsy-confirmed DLB patients, this study may facilitate the accurate diagnosis of DLB in patients suffering from dementia with low MIBG-uptake.