Examining relationships between vascular disease and multiple sclerosis


  • Increased cerebral small vessel disease (cSVD) was associated with worse multiple sclerosis (MS) outcomes.

Why this matters

  • Patients with MS and vascular comorbidities – including diabetes, hypertension, hypercholesterolemia and heart disease – have faster progression to disability and lower brain volumes than patients without vascular comorbidities.

  • It is possible that MS is associated with increased severity of vascular disease, both cerebral and systemic; however, studies attempting to link vascular disease and MS to date have been challenging to design and implement and have produced inconsistent results.