Excess mortality in patients with multiple sclerosis

Takeaway

  • Current age and disease duration have differing effects on excess mortality rates in relapsing onset MS (R-MS) and primary progressive MS (PPMS).

Why this matters

    MS is an autoimmune, demyelinating disease which increases mortality and has been shown to reduce life expectancy by 6 to 14 years. This was the first study to determine the excess death rates (EDR) due to MS, with current age and disease duration as covariates.