Exploration of amyloid and tau pathology in drug-resistant temporal lobe epilepsy


  • Hyperphosphorylated tau (pTau) and amyloid-β (Aβ) plaques are uncommon in epileptogenic temporal lobe tissues in patients with drug-resistant temporal lobe epilepsy (TLE), and amyloid pathology is not related to epilepsy clinical characteristics.

Why this matters

  • Previous studies investigating the contributions of pTau and Aβ plaques to cognitive decline in TLE have been inconclusive.

  • Results from this study suggest that there is no role for amyloid pathology cognitive decline of patients with TLE and advocate for additional follow-up to further elucidate the role of pathology on long-term cognitive function and seizures.