Exploration of potential biomarkers for spinal bulbar muscular atrophy

Takeaway

  • Creatine kinase (CK), creatinine (CR), and neurofilament light chain (NfL) levels are significantly different in spinal bulbar muscular atrophy (SBMA) compared with amyotrophic lateral sclerosis (ALS).

Why this matters

  • This study indicates a helpful biomarker panel to differentially diagnose SBMA from ALS is normal NfL levels, increased CK, and decreased CR levels.