Expression of cutaneous beta-2 adrenoceptors in complex regional pain syndrome

Takeaway

  • Distribution of cutaneous beta-2 adrenoceptors (β2-ARs) is similar in affected and contralateral limbs of people with complex regional pain syndrome (CRPS) with no difference between patients and pain-free volunteers.

Why this matters

  • Preclinical studies suggested that cutaneous β2-ARs may be increased in people with CRPS, however, this study shows no association between expression in keratinocytes and CRPS characteristics except a potential role in thermal hyperalgesia in a patient subgroup.