Extending REM sleep definition using theta-gamma cross-frequency coupling in the hippocampus


  • Theta-gamma coupling in the hippocampus and neocortex is dynamically modulated within single rapid eye movement sleep (REMS) episodes.

Why this matters

  • REMS and non-REM sleep (NREM) are associated with memory acquisition, but the underlying mechanisms of memory consolidation during REMS remain unclear.

  • Demonstration of theta-gamma cross-frequency coupling (CFC) modulation in the hippocampus during single REMS episodes extends criteria for defining REMS state.