Takeaway
A mouse middle cerebral artery model of ischemic strokesuggests that the inflammasome NLRP3 (NATCH [NAIP (neuronal apoptosis inhibitor protein), C2TA (class 2 transcription activator of the MCH), HET-E (heterokaryon incompatibility) TP1 (telomerase-associated protein)], LRR [leucine rich repeat], and PYD [PYRIN] domains-containing protein 3) is not involved in the acute phase of ischemic stroke and does not exacerbate injury.
Why this matters
Identification of immune system players in the development of ischemic brain injury will provide viable targets for therapeutic intervention.