Faster cognitive decline in people with mixed pathological changes compared with one type of change

Takeaway

  • People with neuropathologic changes from mixed Alzheimer's disease (AD) and Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) were found to have cognitively declined quicker than people with either ‘pure’ AD or ‘pure’ LATE pathologies.

Why this matters

    These results highlight the importance of considering mixed pathologies in informing diagnosis and prognosis as relates to cognitive decline later in life.