First study to present the prognostic value of non-invasive interictal ripple propagation mapping in MRE


  • High-density EEG and magnetoencephalography (MEG) can map interictal ripple and its onset of propagation in children with medically refractory epilepsy (MRE). This may augment epilepsy surgical planning and improve surgical outcomes.

Why this matters

  • Identifying the epileptogenic zone for surgical resection in children with MRE is challenging. An invasive evaluation using intracranial EEG is usually recommended, which allows estimation of the seizure onset zone.

  • With the unpredictable nature of seizures, recording can be time- and resource-consuming. Interictal biomarkers that estimate the epileptogenic zone in a non-invasive manner would be paramount.