Four novel risk genes for Alzheimer’s disease identified

Takeaway

  • Genetic analyses highlighted the importance of microglial response to amyloid deposition in Alzheimer’s disease, and identified four novel disease risk genes: OAS1, LAPTM5, ITGAM/CD11b and LILRB4.

Why this matters

    These results provide insights into the mechanisms underlying Alzheimer’s disease which may help improve in both understanding Alzheimer’s risk and in development of new drug treatments.