Freezing of gait is common in progressive supranuclear palsy and may share pathophysiologic features with speech dysfunction.
Why this matters
This is the largest study of its kind to date. The high incidence of freezing of gait in progressive supranuclear palsy and its association with speech suggests a shared pathophysiology. Since studies indicate that lesions in the supplementary premotor areas lead to speech deficits and freezing of gait, stimulation of this motor area could represent a potential therapeutic strategy.