Fronto-temporal vulnerability in children with severe traumatic brain injury


  • Traumatic brain injury (TBI) in children leads to axonal damage and atrophy in white matter (WM) tracts and a frontotemporo-thalamic network; these tissue changes are linked to severity of injury and subsequent disability, as well as cognitive impairment.

Why this matters

  • These findings are the first to demonstrate a brain network that remains particularly susceptible to axonal damage and atrophy during the chronic stage of TBI; these changes could contribute to cognitive impairment post-injury.