Functional connectivity and white matter damage in people with vascular cognitive disorder


  • Poor brain functional connectivity (FC) between hemispheres and within the central executive network (CEN) is associated with cognitive impairment in people with vascular cognitive disorder (VCD); white matter tract (WMT) damage may mediate poor FC associated with cognitive impairment.

Why this matters

  • The pathology of VCD is thought to be caused by damage to white matter pathways that leads to a disconnection of cognitive networks in structural areas distant from the lesion.

  • It is unknown if distinct patterns of FC are associated with brain tissue damage and cognitive impairment, and this knowledge may contribute to the development of clinical treatments for VCD.