Functional connectivity changes associated with complex migraine aura compared with migraine without aura

Takeaway

  • Visual pathways are prominently involved in migraine with aura (MwA) pathophysiology, and higher resting-state functional connectivity (RS-Fc) of the visual network may promote complex migraine aura.

Why this matters

    Resting state functional magnetic resonance imaging (RS-fMRI) studies evaluating differences in visual network RS-Fc between simple aura and complex aura do not exist. The present study provides a hypothesis for propagation of complex aura phenotypes and may have future treatment implications.