Functional connectivity in deep brain stimulation for obsessive compulsive disorder

Takeaway

  • Improvements in mood and anxiety in those with obsessive compulsive disorder (OCD) undergoing chronic deep brain stimulation (DBS) correlates with functional connectivity changes between the left laterobasal amygdala and right insula.

Why this matters

    Improvements in anxiety and mood in OCD through modulation of the ventromedial prefrontal cortex-amygdala-insula circuit suggests DBS of this region may be beneficial in other treatment-resistant anxiety or depressive disorders.