Functional magnetic resonance image patterning of brain entropy in temporal lobe epilepsy patients


  • Right temporal lobe epilepsy (rTLE) patients have significantly altered patterns of brain entropy compared to healthy controls; in addition, intrinsic and phasic alertness are positively associated with decreasing brain entropy in the right precentral gyrus.

  • Altered brain entropy may be associated with a reconstruction of brain functional connectivity in patients with rTLE.

Why this matters ?

  • Entropy is a known non-linear parameter that has been used to characterize brain states through analysis of electrophysiological data. It has been shown to be significantly higher during seizures in people with epilepsy; changes in alertness also affect entropy.

  • Use of functional magnetic resonance imaging (fMRI) to map brain entropy could clarify the pathophysiology of rTLE.