Functional network analysis of cognitive impairment in multiple sclerosis


  • In this study of people with multiple sclerosis (MS), one in five had a lower cognitive status after a period of five years. This was associated with underlying cognitive network disruption, that includes the visual attention network (VAN) and the default-mode network (DMN).

Why this matters

  • Cognitive impairment impacts 40­–70% of patients with MS, but the mechanisms underlying conversion from mild to severe impairment are unknown.

  • The DMN has recently been identified as a key brain network involved in cognition, that is usually suppressed by the VAN during cognitive tasks. However, it is unclear which specific cognition-related networks are affected in cognitive impairment development.