Functional profile method modeling of basal ganglia dynamics in Parkinson’s disease


  • A new approach, the functional profile method (FPM), was investigated to study the basal ganglia motor circuit (BGmC) in those with Parkinson’s disease (PD), indicating that the BGmC acts like a multiple covariance network which is inhibited in those with PD compared with healthy controls.

Why this matters

    This initial study utilizing the FPM indicates it may be useful for investigation of the basal ganglia and other complex brain networks in a variety of diseases.