GABA neurons regulate noradrenergic-mediated arousal

Takeaway

  • GABA neurons in the locus coeruleus (LC) inhibit noradrenergic activity to control arousal levels in the brain.

Why this matters ?

  • Mechanisms regulating noradrenergic neuronal activity are poorly understood; this study demonstrates local LC-GABAergic neurons regulate the gain and tone of noradrenergic-mediated arousal.