Generalizing brain scans to the clinical setting in people with aphasia


  • In people with aphasia caused by stroke, lesion growth is a confounding variable that may prevent the generalizability of research databases being used in a clinical setting; however, modeling lesion growth overtime may correct this bias and improve clinical diagnosis.

Why this matters

  • One-third of people with stroke develop aphasia, and current imaging techniques cannot predict when language will recover.

  • Building structural databases may help to predict clinical outcomes of language acquisition; however, the limits of generalizability, native language, imaging method, and assessment timing, are unknown.