Genetic and environmental factors contribute equally to amyotrophic lateral sclerosis development

Takeaway

  • Overall, half of the variance observed in the risk of developing amyotrophic lateral sclerosis (ALS) is accounted for by genetics, with C9orf72 being a key determinant of heritability.

  • Increased heritability in mother–daughter pairings indicates gender-associated transmission.

Why this matters

    Identifying the heritability of ALS will provide insight on the benefit of genetic testing and predicting disease risk in individuals with a family history of ALS.