Genetic association between glycemic traits, diabetes and cerebrovascular disease


  • Genetic predisposition to type 2 diabetes (T2D) and hyperglycemia are associated with a higher risk of large artery and small vessel ischemic stroke (IS).

Why this matters

  • Mendelian randomization (MR) uses genetic variants as instruments for traits of interest and has proven a powerful method for inferring causality; this may prove useful in determining predisposition for IS by exploring related traits including insulin resistance.

  • Identification of individuals predisposed to higher IS risk may lead to early preventative measures to reduce IS incidence, and consequently both improve patient outcomes and relieve financial burden on healthcare providers.