Genetic basis of insulin resistance in small vessel stroke and Alzheimer’s disease

Takeaway

  • Insulin resistance may have a genetically based causal role in small vessel stroke and Alzheimer’s disease (AD).

Why this matters

  • Cerebral small vascular disease (CSVD) and AD are common pathologies with overlapping risk factors that include hypertension and altered glucose metabolism.

  • Insulin resistance has been associated with stroke, CSVD, and AD, but evidence for a causal role in previous Mendelian randomization studies – a study design that simulates a randomized control trial – has been mixed.

  • Further investigation of insulin resistance in CSVD and AD using a Mendelian randomization approach is warranted.