Genetic factors drive high interictal magnetoencephalography power and connectivity in genetic generalized epilepsy


  • Individuals with genetic generalized epilepsy exhibit bilateral, widespread and highly increased power and connectivity that are partially shared with their asymptomatic siblings.

Why this matters

  • A polygenic background for genetic generalized epilepsy has previously been proposed.

  • Imaging metrics based on oscillatory neural activity and measured by magnetoencephalography during resting-state could represent an endophenotpye of this form of epilepsy. The unique network features identified here are likely driven by genetic factors rather than active disease and could serve as markers to link imaging with genetics in epilepsy.