Genetic frontotemporal lobar degeneration disorders have distinctive atrophy patterns that are mutation-specific

Takeaway

  • People with genetically determined frontotemporal lobar degeneration disorders have greater gray matter disruption compared with sporadic cases.

Why this matters

    This unique study uses innovative volumetric magnetic resonance imaging to provide a comprehensive report of clinical and gray matter findings in people with genetic frontotemporal lobar degeneration disorders. The findings suggest that neuroimaging can provide useful volumetric measures that are applicable to clinical trials as well as highlighting possible neuroimaging markers of underlying pathology that could help to elucidate the heterogeneity of this spectrum of disorders.