Genetic predisposition to mosaic chromosomal loss is linked to worse functional outcome following ischemic stroke

Takeaway

  • An exploratory analysis reveals that autosomal loci predisposing to loss of chromosome Y are associated with worse functional outcome after ischemic stroke.

Why this matters

  • Wide variations in functional outcomes after ischemic stroke are only partly explained by clinical factors; this exploratory study sought to elucidate the underlying molecular mechanism for this disparity.

  • The findings suggest that inherited genetic variants constituting the polygenic risk score affect recovery after stroke and that these may be linked to sex chromosomes. Being able to detect these mutations would help to identify those individuals who may need additional interventions to support brain recovery after a stroke.