Genetic risk factors for sporadic amyotrophic lateral sclerosis


  • Tumor protein 73 (TP73) was identified as a novel risk gene for the development of sporadic amyotrophic lateral sclerosis (SALS), indicating a potential role of motor neuron apoptosis in disease pathology.

Why this matters

  • Up to 61% of risk has been attributed to genetic factors in SALS, but most genetic risk factors for this form of the disease are unknown.

  • tp73 is a protein in the p53 family of tumor suppression transcription factors that has not yet been associated with SALS pathogenesis.