Genetics analyses of kidney function and the risk of developing cerebrovascular diseases

Takeaway

  • There may be a causal relationship between impaired kidney function and certain ischemic stroke (IS) subtypes.

Why this matters

  • Globally, stroke is the second leading cause of death. Up to 35% of stroke patients have chronic kidney disease (CKD), and people with severely impaired kidney function are at increased risk of stroke.

  • Genetic studies (using Mendelian randomization; MR) can overcome the limitation of observational studies in that the latter do not inform on shared pathogenesis or causal relationships between two traits.