Genome-wide association analysis for benign childhood epilepsy with centro-temporal spikes

Takeaway

  • Benign childhood epilepsy with centro-temporal spikes (BECTS) is partially heritable and associated with single nucleotide polymorphisms in KALRN, CHRNB4, and PTCHD3/RAB18.

Why this matters

  • Studies have found an increased risk of BECTS within families; however, this could be due to shared genetic or environmental causes.

  • Twin studies have not supported a major genetic contribution; however, larger scale studies could reveal a link.