Genome-wide screening for type 1 collagen dysregulation in preclinical dementia

Takeaway

  • New variants in genetic factors regulating type 1 collagen turnover have been discovered that are significantly associated with preclinical dementia in post-menopausal women.

Why this matters

  • Regulation of type 1 collagen is impaired during inflammatory disease, resulting in an imbalance between degradation of old collagen fibers and synthesis of new replacements which can further drive inflammation.

  • Matrix metalloproteinase-degraded type 1 collagen (C1M) is a blood-based biomarker of collagen dysregulation and inflammation associated with early death, fibrosis, cancer and rheumatoid arthritis in post-menopausal women; however, little is known about the genetic factors underlying this association.