Genome-wide study discovered variants associated with Alzheimer’s disease endophenotypes

Takeaway

  • Novel genetics insights shed light on the biology variability of different (Alzheimer’s disease) AD endophenotypes based on vascular burden.

Why this matters

    The genetics behind the clinical heterogeneity of Alzheimer’s disease (AD) is poorly understood. This study points to different biological processes underlying AD variation that could lead to novel therapeutic targets and strategies.