Glial fibrillary acidic protein can identify MRI abnormalities


  • The area under the receiver operating characteristic curve (AUC) for plasma concentration of glial fibrillary acidic protein (GFAP) to discriminate between patients with CT-negative traumatic brain injury (TBI) and MRI-positive lesions versus CT-negative and MRI-negative was 0.777 within 24h of injury, suggesting that GFAP has the discriminative ability to identify MRI abnormalities in patients with normal CT findings.

Why this matters

  • This suggests a greater role for MRI in the diagnosis of TBI.

  • Analysis of GFAP concentrations within 24 h of injury may improve detection of TBI and identify patients who may need subsequent MRI and follow-up.